Downstream Processing Senior Scientist

Pobočka: UK - Hertfordshire - Stevenage
Datum zveřejnění: Apr

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Downstream Processing Senior Scientist

We are seeking an experienced and passionate Downstream Processing Senior Scientist to join our Enzyme and Oligonucleotide Development group in Stevenage, UK.

This is an exciting opportunity to be at the forefront of an exciting and growing area, shaping the future direction of innovative medicines and playing a key role in developing our scientific approach to Oligonucleotide development and manufacture.

The successful candidate will have extensive experience in bioprocessing and be an expert in key bioprocessing unit operations, with a focus on chromatography and ultrafiltration. They will help develop downstream purification processes for our oligonucleotide products, working closely with key stakeholders in partner groups such as analytical, process engineering and clinical and commercial manufacturing. They will also play a key role in the development of our oligonucleotide purification platform, collaborating internally and externally to explore cutting-edge scientific approaches and technologies.

In this role you will

• Support the development of robust downstream purification processes for oligonucleotide products, both in early and late-stage development, working with members of the process development team.
• Author/contribute to detailed technical reports and process transfer documents to support tech transfer activities, and engage with manufacturing teams to ensure successful campaign completion.
• Stay current with the latest downstream technology improvements and process development approaches, leading continuous improvement efforts to maintain GSK's technical competitiveness and play a key role in platform development.
• Contribute to project and matrix teams to deliver both the GSK portfolio and technology development objectives

Basic Qualifications/Experience:

We are looking for professionals with these required skills to achieve our goals:

• MSc or Bachelor's degree in Biochemistry, Biotechnology, Biochemical/Chemical Engineering, or a related discipline
• Proven academic or Industrial experience in Biologics/Oligonucleotides and/or Biomanufacturing

Preferred Qualifications/Experience:

If you have the following characteristics, it would be a plus:

• PhD in a related discipline and/or relevant industrial experience, and experience of helping develop purification processes for Oligonucleotides
• An understanding of oligonucleotide chemistry, structure, and properties to inform purification process design
• Knowledge of Quality by Design (QbD) principles and their application to downstream process development

Closing Date for Applications - Thursday 8th May 2025

Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

GSK R&D

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We're uniting science, technology and talent to get ahead of disease together.

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