Principal Scientist
Posted 6 hours 29 minutes ago by GlaxoSmithKline
Posted Date: Apr
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Principal Scientist, Computational Chemistry
We are seeking a highly motivated Principal Scientist within the Molecular Design team to support research activities across multiple therapeutic areas and drug modalities. The position will involve application of computational chemistry methods and innovative science to drug discovery programs. You will get the opportunity to work in a large computational science department interacting with a range of talented scientists, across the UK and US, with various backgrounds and experience.
We are looking for this role to be based at Stevenage, UK.
In this role you will
- Apply cutting edge computational chemistry techniques to drive multiparameter optimisation in drug discovery programs
- Work on inter-disciplinary teams providing computational design of experiments, including data generation to strengthen models
- Develop new capabilities and infrastructure which assist other scientists in their work and maintain GSK's powerful suite of design tools
- Work closely with colleagues from other disciplines in a matrix environment, communicating complex scientific ideas to partners with a range of backgrounds
Basic Qualifications/Experience:
We are looking for professionals with these required skills to achieve our goals:
- PhD, MSc or equivalent in chemistry, pharmacy or a closely related discipline
- Experience in one or more of the following: Virtual screening, structure-based and ligand-based approaches to design small molecules, Machine Learning and QSAR modelling, Free Energy prediction.
- Demonstrated scientific contributions documented with publications and/or presentations
Preferred Qualifications/Experience:
If you have the following characteristics, it would be a plus:
- Knowledge of the drug discovery process, for example medicinal chemistry, toxicology, DMPK, and/or screening data analysis
- Experience with commercial modelling tools, eg Schrodinger, CCG, etc
- Experience in python scripting
- Strong knowledge of chemical and protein structure
- Experience with PROTAC or Antibody Drug Conjugate (ADC) design
- Experience with array design or synthetic tractability prediction
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
GSK R&D
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We're uniting science, technology and talent to get ahead of disease together.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
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