Proteomics Scientist
Posted 10 days 23 hours ago by The John Innes Centre
Permanent
Full Time
Other
Norfolk, Norwich, United Kingdom, NR1 1
Job Description
Hours per week 37 Project Title The role will be based in the JIC Proteomics Platform. This position is for a Proteomics Specialist, who will help serve the growing needs of proteomics-based technology at the John Innes Centre (JIC). Months Duration Indefinite
Job Description Main Purpose of the Job The Proteomics Scientist will work within the Proteomics Platform at JIC to provide proteomics support to a diverse array of researchers. The role will span multiple aspects of complex proteomics experiments, including advising on experimental design, instrument maintenance and operation, method optimisation, data analysis pipelines, interactions with users/clients, training, sample preparation, data processing, presentation of data, and contributions to associated manuscripts.
Key Relationships Internal: Line manager, proteomics platform manager and, as necessary, other researchers, research support staff and students across the Institute.
External: TSL proteomics team associated with equipment sharing; other clients and collaborators from external institutions; engineers and support specialists associated with proteomics equipment.
Main Activities & Responsibilities Percentage
Specialist Knowledge & Skills Requirement Importance Expertise in running proteomics experiments Essential Ability to analyse complex protein sample types Essential Proficiency with common mass spectrometry proteomics data analysis software Essential Knowledge in protein separation and enrichment sciences. Essential Knowledge and interest in biological protein structure, function and interaction. Essential Proficiency in data dependent and data independent acquisition modes as well as isobaric labelling methods. Desirable
Requirement Importance Experience of oral research presentations and written presentations Essential Experience of supervising, training and mentoring visitors and students Desirable Preparing data / information for grant proposals Desirable Experience in working with different types of mass spectrometers including Orbitrap and MALDI-TOF Desirable Experience with mass spectrometry imaging for the analysis of small molecules Desirable
Interpersonal & Communication Skills Requirement Importance Excellent communication skills, both written and oral, including the ability to present complex information with clarity Essential Good interpersonal skills, with the ability to work as part of a team Essential Demonstrated ability to work independently, using initiative and applying problem solving skills Essential Excellent time management and organisational skills Essential Ability to collaborate with internal and external stakeholders Essential Ability to follow instructions/Standard Operating Procedures Essential Promotes and strives for continuous improvement Essential
Additional Requirements Requirement Importance Promotes equality and values diversity Essential Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work Essential Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute Essential Ability to maintain confidentiality and security of information where appropriate Essential Willingness to work outside standard working hours when required Essential Ability to undertake occasional travel (national and international) related to collaborations and/or seminars Essential Attention to detail Essential
Who We Are The John Innes Centre is an independent, international centre of excellence in plant and microbial genetics, carrying out fundamental and strategic research, to train scientists and making our findings available to society.
Our research makes use of a wide range of disciplines in the biological and chemical sciences including; cell biology, biochemistry, chemistry, genetics and molecular biology.
We pride ourselves on being a welcoming and inclusive working environment for all. We have a diverse and multicultural scientific community and thrive on our European and international links, appointing staff from across the world.
We are proud to hold a prestigious Athena SWAN Gold award, recognising the impact of our work in promoting gender equality in science. We are also a proud member of the Stonewall Diversity Champion's programme, a founding signatory of the Technician Commitment and, as a Disability Confident employer, guarantee to offer an interview to all disabled applicants who meet the essential criteria for the post.
The John Innes Centre is a registered charity (No. 223852), limited by guarantee (registered in England No. 511709).
Department To be agreed
The position will be placed in the JIC Proteomics Facility team and help provide a comprehensive Proteomics service to JIC, as well as for the wider Norwich Research Park and other external partners.
Proteomics Scientist
Salary: £36,720 - £44,500 per annum depending on qualifications and experience.
Contract: Indefinite, full-time.
Location: John Innes Centre, Norwich, UK.
Closing date: 2 March 2025
Reference:
The John Innes Centre (JIC) seeks a talented, motivated individual as a proteomics specialist to serve the growing needs of proteomics-based technology at JIC, which is a globally recognized, independent research institute specializing in plant and microbial sciences.
About the Proteomics Platform Group:
The position will be in the JIC Proteomics Platform team, which provides a comprehensive Proteomics service to JIC, as well as for the wider Norwich Research Park and other external partners. The platform is equipped with state-of-the-art mass spectrometers, including a Thermo Orbitrap Eclipse Tribrid equipped with a FAIMS PRO DUO interface. A MALDI source is also available to perform MALDI imaging on the Orbitrap Eclipse.
Further instruments include a Burker MALDI-TOF and a Waters Synapt G2-Si Q-TOF. These facilities allow for a broad range of methods including analysis of individual proteins, the qualitative and quantitative analysis of complex protein samples (e.g. CoIPs, expression studies, modifications, isotope labelling), as well as mass spectrometry imaging and ion mobility. We offer collaboration, service and advice across the Norwich Research Park, the wider research community and commercial users.
The role:
Applications are invited for an enthusiastic and talented proteomics specialist to join our Proteomics Platform in a full-time, indefinite post. The specialist will work alongside an experienced platform manager to support proteomics projects, including instrument maintenance and operation, sample preparation, method optimization, data analysis pipelines, interactions with users/clients, advising on experimental design, and training. The specialist will also assist with data processing and contribute to associated research papers.
While the work is focused on proteomics on the Orbitrap Eclipse, the role will also involve the operation and maintenance of several advanced mass spectrometers (Thermo Orbitrap Eclipse, Burker MALDI-TOF, Waters Synapt Q-TOF) including the requisite software and nano-scale liquid chromatography systems. The specialist will prepare samples for proteomics analysis including protein quantification, enzymatic digestion, isobaric labelling, and sample clean up. Projects will be further supported by employing efficient and accurate data evaluation techniques, and the role will involve close interactions with research groups to aid with experimental design, data analysis and associated training.
The ideal candidate:
The ideal candidate will have substantial experience in proteomics-based work and a PhD in a relevant subject. Hands-on experience in the application of mass spectrometry/LC-MS techniques to the detailed characterization of proteins is essential for this role.
They will have knowledge in protein separation and enrichment sciences, as well as an interest in biological protein structure, function and interactions. Knowledge and proficiency in the operation of advanced Orbitrap, MALDI and Q-TOF mass spectrometers is highly desirable . click apply for full job details
Job Description Main Purpose of the Job The Proteomics Scientist will work within the Proteomics Platform at JIC to provide proteomics support to a diverse array of researchers. The role will span multiple aspects of complex proteomics experiments, including advising on experimental design, instrument maintenance and operation, method optimisation, data analysis pipelines, interactions with users/clients, training, sample preparation, data processing, presentation of data, and contributions to associated manuscripts.
Key Relationships Internal: Line manager, proteomics platform manager and, as necessary, other researchers, research support staff and students across the Institute.
External: TSL proteomics team associated with equipment sharing; other clients and collaborators from external institutions; engineers and support specialists associated with proteomics equipment.
Main Activities & Responsibilities Percentage
- Operate and maintain several advanced mass spectrometers including the requisite software and nano-scale liquid chromatography systems 20
- Prepare samples for proteomics analysis including protein quantification, enzymatic digestion, isobaric labelling, sample clean up 20
- Run samples on a nanoLCMS system with an Orbitrap Eclipse mass spec for proteomics analysis 20
- Process mass spec raw data for peptide/protein identification and quantification 10
- Support proteomics projects through employing efficient and accurate data evaluation techniques, placing levels of statistical confidence on data output, and clearly reporting results 10
- Interact with faculty and staff and present technical data through presentations and report writing 5
- Train others on procedures, operations and new technology, or methods 5
- Ensure research and record keeping is carried out in accordance with good practice, Scientific Integrity and in compliance with local policies and any legal requirements 5
- Contribute methods, data and analysis to associated research publications 5
- As agreed with line manager, any other duties commensurate with the nature of the role.
Specialist Knowledge & Skills Requirement Importance Expertise in running proteomics experiments Essential Ability to analyse complex protein sample types Essential Proficiency with common mass spectrometry proteomics data analysis software Essential Knowledge in protein separation and enrichment sciences. Essential Knowledge and interest in biological protein structure, function and interaction. Essential Proficiency in data dependent and data independent acquisition modes as well as isobaric labelling methods. Desirable
Requirement Importance Experience of oral research presentations and written presentations Essential Experience of supervising, training and mentoring visitors and students Desirable Preparing data / information for grant proposals Desirable Experience in working with different types of mass spectrometers including Orbitrap and MALDI-TOF Desirable Experience with mass spectrometry imaging for the analysis of small molecules Desirable
Interpersonal & Communication Skills Requirement Importance Excellent communication skills, both written and oral, including the ability to present complex information with clarity Essential Good interpersonal skills, with the ability to work as part of a team Essential Demonstrated ability to work independently, using initiative and applying problem solving skills Essential Excellent time management and organisational skills Essential Ability to collaborate with internal and external stakeholders Essential Ability to follow instructions/Standard Operating Procedures Essential Promotes and strives for continuous improvement Essential
Additional Requirements Requirement Importance Promotes equality and values diversity Essential Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work Essential Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute Essential Ability to maintain confidentiality and security of information where appropriate Essential Willingness to work outside standard working hours when required Essential Ability to undertake occasional travel (national and international) related to collaborations and/or seminars Essential Attention to detail Essential
Who We Are The John Innes Centre is an independent, international centre of excellence in plant and microbial genetics, carrying out fundamental and strategic research, to train scientists and making our findings available to society.
Our research makes use of a wide range of disciplines in the biological and chemical sciences including; cell biology, biochemistry, chemistry, genetics and molecular biology.
We pride ourselves on being a welcoming and inclusive working environment for all. We have a diverse and multicultural scientific community and thrive on our European and international links, appointing staff from across the world.
We are proud to hold a prestigious Athena SWAN Gold award, recognising the impact of our work in promoting gender equality in science. We are also a proud member of the Stonewall Diversity Champion's programme, a founding signatory of the Technician Commitment and, as a Disability Confident employer, guarantee to offer an interview to all disabled applicants who meet the essential criteria for the post.
The John Innes Centre is a registered charity (No. 223852), limited by guarantee (registered in England No. 511709).
Department To be agreed
The position will be placed in the JIC Proteomics Facility team and help provide a comprehensive Proteomics service to JIC, as well as for the wider Norwich Research Park and other external partners.
Proteomics Scientist
Salary: £36,720 - £44,500 per annum depending on qualifications and experience.
Contract: Indefinite, full-time.
Location: John Innes Centre, Norwich, UK.
Closing date: 2 March 2025
Reference:
The John Innes Centre (JIC) seeks a talented, motivated individual as a proteomics specialist to serve the growing needs of proteomics-based technology at JIC, which is a globally recognized, independent research institute specializing in plant and microbial sciences.
About the Proteomics Platform Group:
The position will be in the JIC Proteomics Platform team, which provides a comprehensive Proteomics service to JIC, as well as for the wider Norwich Research Park and other external partners. The platform is equipped with state-of-the-art mass spectrometers, including a Thermo Orbitrap Eclipse Tribrid equipped with a FAIMS PRO DUO interface. A MALDI source is also available to perform MALDI imaging on the Orbitrap Eclipse.
Further instruments include a Burker MALDI-TOF and a Waters Synapt G2-Si Q-TOF. These facilities allow for a broad range of methods including analysis of individual proteins, the qualitative and quantitative analysis of complex protein samples (e.g. CoIPs, expression studies, modifications, isotope labelling), as well as mass spectrometry imaging and ion mobility. We offer collaboration, service and advice across the Norwich Research Park, the wider research community and commercial users.
The role:
Applications are invited for an enthusiastic and talented proteomics specialist to join our Proteomics Platform in a full-time, indefinite post. The specialist will work alongside an experienced platform manager to support proteomics projects, including instrument maintenance and operation, sample preparation, method optimization, data analysis pipelines, interactions with users/clients, advising on experimental design, and training. The specialist will also assist with data processing and contribute to associated research papers.
While the work is focused on proteomics on the Orbitrap Eclipse, the role will also involve the operation and maintenance of several advanced mass spectrometers (Thermo Orbitrap Eclipse, Burker MALDI-TOF, Waters Synapt Q-TOF) including the requisite software and nano-scale liquid chromatography systems. The specialist will prepare samples for proteomics analysis including protein quantification, enzymatic digestion, isobaric labelling, and sample clean up. Projects will be further supported by employing efficient and accurate data evaluation techniques, and the role will involve close interactions with research groups to aid with experimental design, data analysis and associated training.
The ideal candidate:
The ideal candidate will have substantial experience in proteomics-based work and a PhD in a relevant subject. Hands-on experience in the application of mass spectrometry/LC-MS techniques to the detailed characterization of proteins is essential for this role.
They will have knowledge in protein separation and enrichment sciences, as well as an interest in biological protein structure, function and interactions. Knowledge and proficiency in the operation of advanced Orbitrap, MALDI and Q-TOF mass spectrometers is highly desirable . click apply for full job details