TM Site Lead United Kingdom (UK)

Job Description Summary

As Novartis, we are an innovative medicines company with research and development (R&D) at our core.

Our R&D engine powers an industry-leading pipeline focused on delivering transformative medicines to fight disease, restore possibility, and help people live life on their own terms. Researchers in BR work across several disease areas to uncover insights into the origins and pathogenesis of disease to drive drug discovery and early development.

Within BR, Translational Medicine (TM) is the clinical research arm including over 900 associates globally. Our TM Experts (TME) apply their medical and research expertise to guide promising therapeutic candidates along the path to development. Our physician-scientists have a deep understanding of disease biology and unmet medical needs. Working shoulder-to-shoulder with our discovery colleagues, and alongside a dedicated team of preclinical safety, pharmacokinetic, biomarker, and clinical scientists, we identify and validate new drug targets, compounds, and biological drugs, and provide insights on where novel therapies can achieve the greatest clinical benefits.

As 'Emerging Therapies' (ETx), we closely collaborate with various Disease Areas focusing on Renal-, Liver-, and Auto-inflammatory Diseases applying various platform technologies ranging from low molecular weight compounds, antibodies, siRNA/ASO, to gene editing therapies.

As the TM Site Lead UK, you will lead a team of TMEs responsible for all early clinical development plans and studies through first in human, first in disease, new diseases, translational research and profiling activities, and clinical pharmacology studies.

You will be a member of the global TM Leadership Team, accountable for overall department goals, helping to lead continuous improvement across the department, and enhancing the culture of TM.

You will also be a key bridge between Research and Late-Phase Development and Commercial colleagues across the Novartis RDC Continuum.

Job Description

As Translational Medicine Expert, major accountabilities include:

• Develop and work with teams to develop and implement strategies for the TM component of drug development projects from Research to Development and Commercialization (RDC) in single or multiple indications, including indication expansion projects.
• Act as key leader in developing Phase 1/2/3 and post-approval profiling strategy for drug programs.
• Lead study-specific teams/clinical trial teams in partnership with other line functions and serve as TM representative on Global Program Teams (GPT).
• Provide support for dose selection, study design, and other clinical pharmacology matters throughout the development cycle.
• Oversee conduct and interpretation of studies supporting pivotal trials, such as special populations, drug-drug interactions, mechanism of action assessments, Pediatric Investigational Plan, etc.
• Participate on Corporate & Business Development (C&BD) teams as the TM representative.
• Represent TM aspects to Health Authorities and other stakeholders.
• Oversee publication strategy for TM studies.

As UK Translational Medicine Site Lead, major responsibilities include:

• Lead successful implementation of the planned TM setup in UK in a phased approach.
• Provide operational leadership of the cross-functional TM team in UK.
• Lead the long-term strategic growth and seamless integration of TM functions in the UK, delivering timely and high-quality support for the TM Portfolio.
• Develop and contribute to strategic business plans for new teams/functions to start up in UK, in close collaboration with global line function leaders.
• Responsible for executing the local TM Strategy, governance, budget, compliance, and talent decisions.
• Serve as a bridge between the global and local teams: integrate and embed Global Novartis & BR culture & ways of working in local TM teams.
• Create a shared sense of purpose, inspire and energize teams through effective communication and engagement.
• Foster and role model a culture of inspired, curious, and unbossed leadership including smart risk-taking in pursuit of novel medicines.
• Lead, inspire, coach, and empower a diverse community of scientists with an emphasis on collaboratively building a talent pipeline for all functions represented on site.
• Ensure effective mentoring and efforts to develop critical scientists/future organizational leaders both on site as well as in close collaboration with the respective TM functions.
• Collaborating across the Research & Development, Commercial (RDC) Continuum.

Minimum requirements:

• MD or MD/PhD, or MD with doctoral thesis in relevant field (e.g., Nephrology, Hepatology, Inflammation, Rare Genetic Diseases).
• Board certification and clinical experience in Nephrology, Hepatology, Internal Medicine, Immunology, Acute Care Medicine or related field.
• Recognized physician-scientist expertise as evinced by publication and/or significant contributions to the field over time.
• Demonstrated passion for science driving innovation and clinical discovery with excellent written and oral communication/presentation skills.
• At least 5 years' experience in a pharmaceutical/biotech company, clinical research organization, or academic medical center, or related experience.
• Able to work independently as outlined above, commensurate with the level of role.

Language:

Fluent English, strong written and oral communication skills.

Why Novartis? Our purpose is to reimagine medicine to improve and extend people's lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us!

Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.