Higher Scientific Officer - Biology, Target Validation and Genome Stability Group

Higher Scientific Officer - Biology, Target Validation and Genome Stability Group Key Information

Salary: Commencement on the salary range is subject to comparable skills and experience. Future progression is based on annual performance review.

This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here .

Duration of Contract: Fixed Term for 2 years

Hours per week: 35 hours per week (Full Time)

Closing Date: 13th January 2025

Under the leadership of Dr. Joanna Loizou, we are seeking to appoint a Higher Scientific Officer to join the Target Validation and Genome Stability group within the Centre for Target Validation to carry out lab-based cell biology research focused on potential therapeutic targets in cancer.

Key Requirements

The successful candidate must have:

• At least a Masters level qualification in Cell Biology or an aligned subject (PhD in Cell Biology or an aligned subject is desirable)
• Knowledge of cancer biology
• Knowledge of experimental approaches to therapeutic target validation in cancer
• Skills in cell biology techniques used for target validation
• Expertise in a range of biology readouts used for screening and biomarker detection
• Experience working in lab-based cell biology (can include PhD)

Department/Directorate Information

The Target Validation and Genome Stability Group, led by Dr. Joanna Loizou, focuses on identifying vulnerabilities in the DNA damage response to generate pre-clinical information that can lead to the identification of novel targets for drug discovery programmes.

The ICR has established a Centre for Target Validation that will accelerate the translation of ICR and collaborator research into drug discovery programmes. The Centre will deliver bespoke, hypothesis-driven data packages to support decision-making for the launch of drug discovery projects. The Centre's dedicated resources, including biology, functional genomics, assay sciences, chemistry, and bioinformatics teams, will support joint project teams that combine the deep biological and therapeutic knowledge of ICR investigators with the validation and technical expertise of drug discovery scientists. Scientists in the Centre for Target Validation will work closely with colleagues in the ICR's Centre for Protein Degradation to exploit emerging technology and protein degradation tools for robust target validation experiments. The Centre for Target Validation will serve as a hub, connecting researchers to expertise and resources that will validate and streamline robust targets into drug discovery programmes in the ICR's Centre for Cancer Drug Discovery or into collaborative programmes with external commercial therapy discovery partners.

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr. Joanna Loizou via Email on .

About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here .

We look forward to receiving applications from all candidates, wherever in the world they are currently based. We will select those who display the potential to become, or to support, the world leading cancer researchers of the future based on their application and performance at interview. However, we particularly welcome British applicants from black and ethnic minority backgrounds, as they are under-represented within the ICR and nationwide in STEM roles.

Salary Range: £35,844 - £48,224 per annum